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KMID : 0355220080330010059
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Journal of Korean Academy Oral Medicine
2008 Volume.33 No. 1 p.59 ~ p.66
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Usefulness of RPS4Y Gene on Sex Determination in Human Teeth
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Yoon Wang-Ro
Ahn Jong-Mo
Yoon Chang-Lyuk
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Abstract
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Ribosomal Protein S4Y(RPS4Y) gene is the human sex-linked gene on the Y chromosome.
There are a number of reports on the sex determination using RPS4Y gene analysis for prevention and diagnosis in sex-linked disease. Thus RPS4Y gene is a reliable genetic marker for sex determination in forensic medicine. In general, the sex determination of an unidentified body can be achieved based on anatomical characteristics, but sometimes sex determination was considered to be difficult such as pre-adolescent bodies or decomposed, mutilated bodies.
In this case, Sex determination using PCR method in human teeth produces good results. Because human teeth have a great structural durability, the DNA well preserved in the teeth.
So author isolated nuclear DNA from the 20 human teeth (10 males, 10 females), performed to detect RPS4Y gene by PCR method. Samples were divided four group (10 pulp and 10 dentinal tissue in male, 10 pulp and 10 dentinal tissue in female). It was found that detection of RPS4Y gene for sex determination was possible in all the male pulp tissues and 6 out of 10 male dentinal tissues. But there was not detected in female pulp and dentinal tissues.
In the view of this results demonstrates the possibility that detection of RPS4Y gene with other sex chromosome genes from the human teeth is useful to sex determination in forensic medicine.
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KEYWORD
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Sex determination, Teeth, RPS4Y gene
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